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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

10.1046/j.1471-4159.1994.63030910.x J

Week-by-Week Timeline (Standard 10-Day Cycle) Days 1-3: Loading Phase Mostly Subjective The first 2-3 days of a 10-day cycle are when plasma LR3 IGF-1 is climbing toward steady-state