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paper proposed to use POLY-SVM, RBF-SVM and normalized POLY-SVM method in predicting the drug permeability of BBB which is based on clinical features 29

Secondary route: FAK/paxillin and fibroblast adhesion BPC-157 also activates focal adhesion kinase (FAK) and paxillin, two key proteins in cell adhesion

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These include the nitric oxide (NO) signaling system, angiogenic responses via VEGFR2, and antioxidant defense mechanisms involving HO-1 and other key enzymes (Jzwiak et al