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Interestingly, 2 unbiased drug repurposing screens of SCA3 cellular and animal models identified compounds that modulated neurotransmission as suppressors of mutant ATXN3 pathogenesis [164, 165]

Recovery is half the equation: BPC-157 and TB-500 do not directly stimulate GH, but they accelerate tendon, ligament, and muscle tissue repair, allowing patients to train with greater frequency and intensity without connective tissue breakdown limiting progress

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In addition, recent exploratory studies have found increased serum BDNF levels following holistic neuro-rehabilitative approaches, including computer-assisted cognitive enhancement in schizophrenia 20 , aerobic exercise in stroke 21 and mindfulness clinical trials in bipolar-disorder 22