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Although AMPK dependent signaling pathway and autophagy were excluded from hepatoprotective mechanism of metformin [59], there are still many events probably being involved in the protective effects, including inhibition of hepatic gluconeogenesis, MPT and ROS production [55]

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FMT has also moved into clinical trials for PD: a Phase II placebo-controlled trial (single nasojejunal infusion of donor stool) in early PD reported a mild but Statistically Significant improvement in motor symptoms at 12 months compared to sham transplant