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The Main Picture is a Schematic Diagram, And The Actual Shape Received May be Slightly Different

Together with evidence that the activation pattern of Nrf2 is rather short-lived but can be re-activated by repeated exposure, we can now understand a manner by which this pathway is persistently activated through chronic, daily exposure to cigarette smoke (and other environment toxins) leading to selection for cells and tumors predisposed toward chemoradiotherapy resistance