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In the body, it regulates metabolism in the epiphysis, increases the sensitivity of the hypothalamus to its natural hormonal influences, and normalizes the function of the anterior pituitary, including its regulation of gonadotropins and melatonin

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Endotoxin administration increases hypothalamic somatostatin mRNA through nitric oxide release

Accessed 1 Apr 2014 Ask M, Bettiga M, Mapelli V, Olsson L (2013a) The influence of HMF and furfural on redox-balance and energy-state of xylose-utilizing Saccharomyces cerevisiae