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11 Conclusion The convergence of tinnitus and neurodegenerative diseases on shared pathological mechanisms, including chronic neuroinflammation, synaptic dysfunction, and excitotoxicity, has prompted a conceptual shift in understanding tinnitus not merely as a symptom but as a disorder of neural plasticity and resilience

2015;6(37):39398-407 Dong Y, Zhang M, Wang S, et al

Further, controlled clinical studies simulating NSW provide causal evidence that melatonin secretion diminishes rapidly upon night work exposure and remains suppressed with continued circadian disruption 183