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As people age their glutathione production capabilities diminish

Niwa R, Nomura Y, Osaki M, Ezawa T

There are many reasons why someone may have poor glutathione status: Low precursors (cysteine, glutamate, glycine) Chronic oxidative burden and/or inflammation Deficiencies in the nutrients required to generate, process, or utilize glutathione (B6 or selenium) A total and/or functional riboflavin deficiency is the probably the most common culprit responsible for poor glutathione reductase activity

Dry desert air causes constant fluid loss through breathing and evaporation, and alcohol adds dehydration, mineral depletion, and oxidative stress