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With a chronically high sympathetic tone, there is then a need for sympatholysis in skeletal muscles to prevent vasoconstriction via the 1-adrenegeric receptors (58)

J Cell Signal

However, it is important to note that the extended use of topical anti-inflammatory agents and corticosteroids is limited due to their potential long-term adverse effects, such as cataracts and steroid-induced glaucoma (Teo et al., 2023