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7 Clinical outcomes of pharmacotherapy To date, numerous clinical studies including double- or single-blinded randomized clinical trials and split-face studies have been conducted to assess the therapeutic effect of various topical conventional and novel formulations in melasma management as summarized in Table 3

eLife 4 , e09906 (2015)

Scientific Overview: Dihexa is a synthetic hexapeptide analogue known for its high affinity to hepatocyte growth factor (HGF) receptors, extensively studied in molecular biology research for its capacity to modulate neurotrophic signalling pathways

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