The increased synthesis and secretion of ROS and the depletion of antioxidant substances lead to the disruption of oxidative balance, which in turn stimulates many signaling pathways that regulate various processes, including the promotion of cell proliferation and migration, and ECM secretion (83)
The glandular epithelium, organized in a pseudostratified structure, is specialized to secrete critical factors such as leukemia inhibitory factor (LIF), progestogen-associated endometrial protein (PAEP) and heparin-binding EGF like growth factor (HB-EGF) to provide the necessary nourishment for the embryo
Activated caspase-4/5/11 cleaves GSDMD, with its N-terminal fragment forming membrane pores, leading to pyroptosis
Ren, X., Chen, X., Wang, Z