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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 7% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Shelterin consists of six subunits: the two dsDNA binders TRF1 and TRF2 (telomeric repeat-binding factor 1/2), the ssDNA-binder POT1 that forms a subcomplex with TPP1, the TRF2-associated RAP1 subunit, and the central scaffolding subunit TIN2 that binds to TPP1, TRF1 and TRF2, thereby bridging the dsDNA- and ssDNA-binding modules (Fig