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doi: 10.3109/0886022X.2010.510617

At this stage, the disruption of macrophage polarization balance and fibroblast activation work together, pushing the tissue toward a turning point of inflammation self-limiting fibrosis immobilization. This marks the evolution of gout lesions from a functional inflammatory response to the irreversible stage of structural reconstruction

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10.1104/pp.126.1.445 104 PrasadT