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The use of self-help materials should, therefore, be restricted to the use that health professionals make of them during behavioral interventions.27,28 The use of CO-oximetry as a biological support for the recommendation to stop smoking, and individual or group therapy have been shown to be effective only in smokers with low physical dependence.20 Furthermore, it has been shown that interventions designed to improve the social support of smokers who are trying to quit (the help and support of their partner for example) do not increase the abstinence rate in these patients.29 Neither has it been found that the practice of physical exercise during a tobacco cessation program increases the efficacy of the program.30 Pharmacological Therapy Recommendation number 2 in the clinical practice guidelines on treating tobacco use and dependence issued by the Public Health Service of the USA establishes that all patients who are willing to try to quit smoking should be provided with pharmacotherapy that has been shown to be effective by the meta-analyses carried out.1,15 These guidelines define two groups of treatment options: the first-line pharmacotherapies, which have proven efficacy and give rise to only slight side effects

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