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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

This allows time for the injected solution to disperse into the surrounding tissue rather than tracking back up the needle path

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The studies indicated that AHK's presence may have raised collagen type I production, with a threefold increase compared to the control group