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Another factor to consider is individual biochemistry

The catch is that NAD+ levels are widely reported to decline as we age, which many researchers view as one contributor to age related dips in energy and resilience

Mechanistically, it influences gene networks involved in tissue remodeling and exerts protective antioxidant and anti-inflammatory actions, partly through TGF- signaling and regulation of metalloproteinases

Likewise, this notion will be further supported by the detection of expression of particular genes ( Vegfr2, Src, Nos2, Nos1, Nos3, Akt1, Kras, Mapk1, Srf, Foxo1, Nfkb1, and Egr1 ) in hippocampal tissue