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Tukey's 95% simultaneous confidence intervals were used to separate data into groups

What Guidelines Say About Lipid Management on Isotretinoin The American Academy of Dermatology (AAD) guidelines on acne management state that patients with pre-existing hypertriglyceridemia or a family history of lipid disorders should be counseled about dietary fat restriction and the possible addition of a lipid-lowering agent before starting isotretinoin [9]

However, careful optimization of antioxidant dosing, timing, and the integration with standard therapies like chemotherapy and radiotherapy remains crucial to maximize therapeutic benefits while avoiding interference with treatment efficacy

As such, there is no agreed recommended safe dosage, and some side effects might occur depending on individual response