doi: 10.3389/fchem.2024.1292566 Received 11 September 2023 Accepted 23 January 2024 Published 08 February 2024 Volume 12 - 2024 Edited by Sara Martinho Almeida Pinto, University of Coimbra, Portugal Reviewed by Aleksander Bilewicz, Institute of Nuclear Chemistry and Technology (INCT), Poland Carolina De Aguiar Ferreira, Michigan State University, United States Updates Copyright 2024 Randhawa, Carbo-Bague, Davey, Chen, Merkens, Uribe, Zhang, Tosato, Bnard, Radchenko and Ramogida
A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys
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Protocol approach 3: comprehensive repair (thymosin alpha-1 plus BPC-157 plus TB-500) Goal: Immune rebalancing combined with aggressive tissue repair Components: Thymosin alpha-1: 1.6 mg subcutaneously twice per week BPC-157: 250 mcg subcutaneously twice daily near affected tissue TB-500 : 2-5 mg subcutaneously twice per week for loading, then weekly for maintenance Rationale: This three-peptide approach targets immune regulation (TA1), mucosal and tissue healing (BPC-157), and cellular migration plus repair (TB-500)