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Extracellular matrix-inspired dendrimer nanogels encapsulating cyclophosphamide for systemic sclerosis treatment

Reduced inflammation: Chronic inflammation can lead to joint pain, fatigue and autoimmune conditions

On the other hand, other authors have shown that MPP + induces negative effects in astrocytes, such as loss of viability, impairment of energetic metabolism of mitochondria, ROS generation and decrease in the glutamate clearance by astrocytes [81,85,86]

Loss of DDB1-CUL4 or disruption of H2B monoubiquitination impairs this recruitment and weakens transcriptional feedback, underscoring the dual role of this E3 ligase complex in regulating clock protein stability and feedback timing (Tamayo et al., 2015