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It is estimated approximately 50% and 34% of patients with diabetes will be affected by diabetic neuropathy (DN) and DFU over the course of their lifetime, respectively

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Hong C, et al

The ANT crystal structures in both cytoplasmic-open (c-state) and matrix-open states (m-state) locked by two inhibitors bound at the solute binding site, carboxyatractyloside and bongkrekic acid respectively, highlighted a conserved alternating-access transport mechanism 5 enabled by the conformational change upon solute binding at the central cavity 6,7

The frequency distribution of AEs was similar in both treatment groups: for ARA 290, 54 mild, 9 moderate and 1 severe categorizations were recorded, while for placebo, 61 mild and 5 moderate were noted