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279 This mechanism was further elucidated in another study, Su-Hyun et al proposed that during the intracellular endosomal trafficking of the P2Y6 receptor induced by MSU crystals, neutrophil recruitment was enhanced on the basis of the IL-8 expression supported by endosome-dependent signaling

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The method of any one of embodiments 1-76, wherein the composition further comprises an excipient that decreases the release rate of the therapeutic agent