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It raises the heart rate, contradicting the goal of most treatments. The Long-Term Cardiovascular Effects of Nicotine Overall, human studies on nicotine show that: 1,7 Nicotine delivered through non-combustible and pharmaceutical products like NRTs (nicotine replacement therapy) does not increase serious heart problems such as heart attack or stroke People with existing heart disease can safely use NRTs (as long as their condition is under control) The British Heart Foundation also states that nicotine is not linked to major long-term cardiovascular disease: 6 Nicotine, while highly addictive, is not a significant health hazard for people without heart conditions

But the team did not offer its own estimate on how much safer they are