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This route may be useful when swallowing capsules is difficult or when a person prefers an alternative to a liposomal liquid

An evaluation of the role of TDLN in PD-1/PD-L1 checkpoint blockade therapy in two mouse tumor models reveals that immune checkpoint treatment induces CD8+ T cell accumulation in the tumor-draining but not in non-draining LNs (210)abrogated checkpoint therapy, suggesting that TDLNs function as sites of T cell invigoration required for PD-1/PD-L1 checkpoint blockade therapy (211, 212)

Further innovation incorporated stimuli-responsive materials (ultrasound or pH-activated components) to achieve precisely controlled activation (Li et al., 2022)

Their accumulation in biological systems results in analogous clinical outcomes