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Furthemore, an increased serotonin metabolism was demonstrated by diminished hypothalamic serotonin levels, lowered 5-hydroxytryptamine (5-HT)/tryptophan ratios and elevated 5-hydroxyindoleacetic acid/5-HT ratios, indicating dysregulated serotonergic system (Jia et al., 2024)

3.1.3 TG TGs are the primary circulating lipids in the blood, crucial for adjusting energy equilibrium and stimulating the activity of cholesterol transport proteins (8789)

Upon EAE induction, mice develop a relapsing-remitting disease course followed by a phenotypically stable chronic progressive phase [25, 39]