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[14] Local IGF-1 isoforms, mechanical loading, satellite-cell dynamics, and myostatin signaling together form the regulatory web within which any exogenous IGF-1 agonist would be acting another reason that predicting the whole-organism effect of an isolated analog from single-pathway experiments is unreliable

3.3 Evaluation of cytokines and chemokines in tears during clinical study As detailed in the materials and methods section of the manuscript, the concentration of different cytokines and chemokines in tears was analyzed using flow cytometry at four study visits following randomization: V1, V3 (1 month after the initial control or the experimental formulation treatment), V4 (after the 1-week wash-out), and V6 (1 month after the crossover treatment)

Where human data does not exist, we say so explicitly

Further, it suggests that the inflammatory response is also independent of plaque burden