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Formononetin can alleviate nephrotoxicity in methotrexate-, cisplatin-and gentamicin-induced kidney injury and DKD ( via Sirtuin-1-PGC-1 pathway, which plays an important role in kidney protection ( 3.1.2.4 Puerarin Puerarin, the bioactive compound extracted from radix puerariae , exhibits beneficial therapeutic effects on cardiovascular diseases, cancer, diabetes and osteonecrosis