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Understand that the science is still developing

Endurance or intense aerobic exercise is commonly known to stimulate ROS and overproduce active nitrogen species due to the increased metabolism, leading to oxidative stress and related injuries [57]

However, another study using rats showed that protein levels of NAMPT, COX1, and PGC-1a were unchanged in skeletal muscles after 4 weeks of treadmill exercise, and NAD + levels or other mitochondrial readouts were not included 308