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The HNF4 gene encodes 12 isoforms driven by two promoters, with the P1 promoter generating isoforms 16 and the P2 promoter producing isoforms 712 through alternative splicing, which are proposed to orchestrate the transcription of distinct target genes to fulfill diverse biological roles [8,9,10]

It increases LC3-associated phagocytosis (LAP) in macrophages via activation of the Dectin-1-Syk signaling axis and the mTOR pathway, thereby enhancing macrophage capacity to combat infection and resist sepsis progression (277)