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For example, smokers who use cigarettes at the rate of a pack a day elevate the level of carbon monoxide in their blood to three times the level normally present in nonsmokers, and in this respect alone smoking exacerbates any predisposition on the part of the smokers to heart and lung disease and possibly increases the danger of arteriosclerosis

The working group rated outcomes according to GRADE.21 Outcomes rated as critical or important by focus group participants (described below) and working group members were considered during guideline development

Similar to gum, lozenges provide a controlled release of nicotine, helping to manage cravings and withdrawal symptoms

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