DATSmediated cancer cell proliferation inhibition is related to cell cycle arrest, including human hepatoma cells (Wu et al., 2004), gastric cancer cells (Ha et al., 2005), colon cancer cells (Hosono et al., 2005), prostate cancer cells (HermanAntosiewicz & Singh, 2005
Chronic exposure to these factors leads to sustained immune cell activation, which in turn drives mitochondrial dysfunction and elevated ROS levels further amplifying immune activation and inflammatory signaling (Kaliszewska et al., 2021
They can bind to ligands such as metal ions, glutathione, Strep-Tactin, or Strep-TactinXT, respectively
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