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This shrinkage phenomenon has further exacerbated the erosion of the power base of small suburban towns within urban areas, leading to the loss of their developmental resources and voice, thereby engendering a downward spiral of peripheralization

Second, robust clinical trials are necessary to evaluate the efficacy and safety of ferroptosis-targeting therapies

Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy

This systemic inflammation, akin to the processes described in schizophrenia, can traverse the blood-brain barrier or transmit via vagal afferents, subsequently activating microglia and exacerbating neuroinflammatory processes while impairing prefrontal cortex-mediated executive functions including decision-making and emotional regulation (270)