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These signs include unexplained deterioration of vision, altered color vision in one or both eyes, globe subluxation (dislocation of the eye from its socket), corneal opacification, recent development of choroidal folds (abnormalities in the layer of the eye responsible for vision), and optic disc edema (swelling of the optic nerve head)

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A separate analysis found that some DNA modifications remained apparent in a group of hundreds of older children those with an average age of six whose mothers had smoked while pregnant