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Cysteine is known to stimulate glutathione synthesis[23], and cysteine availability is often the limiting factor for intracellular glutathione synthesis[24]

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The in vitro hippocampal-neuron-culture spine-density work used Dihexa concentrations across a wide range, with effects observed at picomolar concentrations [2]

Moreover, nucleus and mitochondria contain multiple substrates for caspase-3 [265], which can also provide insight into the non-essential contribution of caspase-3 to eryptosis, since there are no downstream targets of caspase-3 in erythrocytes due to organelle clearance