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Medications Certain medications have the unfortunate side-effect of significantly suppressing gut motility and MMC function, which can lead to bacteria and archaea hanging around in the small intestine

Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)

However, medications in tablet form need to be crushed for the first 3 months to prevent them from getting stuck in the gastrointestinal (GI) tract or not being absorbed properly

Anti-inflammatory approaches: NSAIDs (celecoxib), omega-3 fatty acids (EPA/DHA) evidence for attenuating inflammatory cachexia in cancer patients