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Many patients with MCAS or Long COVID develop severe chemical sensitivities because their liver's Phase II detoxification pathways are overwhelmed

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gingivalis infection in periodontitis upregulates NCOA4 via the NF-B pathway, promoting ferritin lysosomal degradation and causing a continuous influx of ferrous iron (Fe 2+ ) into the labile iron pool (LIP) ( 2.1.2 Impaired iron efflux and pathological iron accumulation Recurrent microbleeding within the periodontal pocket is a core feature distinguishing periodontitis from other chronic inflammatory diseases and represents the most direct source of iron overload

Part 2: A Review of Human Studies