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TB-500 is based on Thymosin Beta-4, a naturally occurring peptide involved in how cells move and organise particularly in studies looking at actin regulation and cell migration

DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

Peter : I mean have you see what Dom D'Agostino has done