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Whilst we found that melatonin did not affect the concentration of G6P ( Figure 5H ), it did seem to greatly reduce the amount of F6P present in our cell samples, indicating potentially that the key disruption to this pathway occurred at the step where G6P is converted to F6P ( Figure 5E )

The PCBD1 gene does not contain the typical TATA-box and CAAT-box basal promoter elements found in the majority of mRNA encoding genes

One magnetic resonance spectroscopy study suggested that abnormal cerebral glucose metabolism was correlated with abnormal values of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) in brain regions associated with cognition ( There are limitations to the current study