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But the clinical significance is that 60% of combination participants achieved at least 20% weight loss, and roughly 23% achieved 30% or more

In a 2001 editorial published in the European Journal of Anesthesiology , Pollard & Pomfrett describe DSIP as incredibly safe because (a) no dose had ever killed an animal subject in clinical research and (b) no significant side effects apart from transient headache, nausea, and vertigo in humans have been reported.4 But the U.S