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Description

Dissociated hippocampal neurons were transfected with mRFP- -actin and shMet RNA and receptor knock-down was allowed to take place for 48 hours prior to stimulating with 0.5 g (per well) HGF (10 ng/ml), Dihexa or Nle1-AngIV (both at 10 12 M)

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They trigger the activation of adaptive response signaling pathways and, consequently, defense response to various stressors, increasing the resilience and survival of organisms (Figure 4)

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These cells accumulate in various tissues, contributing to chronic inflammation, metabolic dysfunction, and organ degeneration

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Most evidence comes from animal models and in vitro studies

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