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Existen dos estados de glutatin: El tiol reducido (GSH), la forma ms predominante (98% del contenido total del glutatin) El oxidado por disulfuro (GSSG) La produccin de GSH se produce a travs de tres vas principales: Sntesis de novo mediante un proceso de 2 pasos catalizado por la glutamato cistena ligasa (GCL) y la glutatin sintetasa (GS), que est controlada principalmente por los niveles celulares de cistena

Barisic I, Seiwerth S, Sikiric P, Sindic A

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We believe that this limited contribution and non-essentiality of caspase-3 for the execution of eryptosis is associated with the absence of the upstream mitochondrial pathways in mature erythrocytes linked with the expulsion of this particular organelle at the terminal stages of erythropoiesis, as well as downstream effectors