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Despite the rising in OST cessation interventions that are implemented on different populations around the world, only two systematic reviews have been conducted to assess the effectiveness of these programs 10,12

Some key biological causes include: Neurochemical Changes : Nicotine binds to nicotinic acetylcholine receptors in the brain, particularly the 42 subtype, stimulating the release of dopamine and other neurotransmitters that create pleasurable sensations and reinforce smoking behavior

2006, New York: Springer Rao JNK, Scott AJ: The analysis of categorical data from complex surveys: Chi-squared tests for goodness of fit and independence in two-way tables