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On day 0, cells were washed once with DMEM/F12 (Thermo Fisher Scientific, Inc.) and replaced with STEMdiff Endoderm basal medium with 1X supplement MR and 1X supplement CJ

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In the normal myometrium, homeostasis is achieved with the assistance of matrix metalloproteinases (MMP), which are involved in remodeling and degrading certain constituents of the extracellular matrices, such as collagen, which contributes to the stiffness of ECM (Korompelis et al., 2015)