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Recent studies have suggested that IF inhibits the nuclear factor kappa-B signaling pathway, which is an important regulator of downstream parameters including TNF- and IL-6 (25), which is consistent with the results that IF could partly eliminate the inflammation caused by adipose tissue, with lower CRP and TNF- (26)

In terms of interventions [258], treatment with exosomes derived from stem cells obtained from human exfoliated deciduous teeth (SHED-exos) promotes salivary flow rate in NOD mice while reducing caspase-3 levels and the number of apoptotic cells in the submandibular glands (SMGs)