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Moreover, there is a direct correlation between the degree of MBP citrullination and the aggressiveness of white matter inflammatory activity in MS patients (Moscarello et al., 2007)

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Taken together, the researchers concluded that thyroid function may affect mast cells, and that mast cell degranulation could affect thyroid function.[ref] In patients with autoimmune thyroid disease, mast cells infiltrate the thyroid gland and then degranulate.[ref] Animal studies show that hypothyroidism (low thyroid hormone levels) increases the number of mast cells by up to 4.5-fold