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Smoking, cigarette smoke exposure, tobacco smoke or pollutants in the air contact directly with the airway, through the way to the lungs, causing a variety of airway diseases, such as COPD, asthma, cystic fibrosis and lung cancer

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This indicates that factors other than environmental or developmental or stress situations can induce changes in GFP expression

Respiratory symptoms relate to physiological changes and inflammatory markers reflecting central but not peripheral airways: a study in 60-year-old healthy smokers and never-smokers