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The FDA flags many research compounds with limited human safety data

In general, but not necessarily, the homozygous variant, often the minor allele, may confer to the affected individual a higher susceptibility in comparison with the homozygous wild-type and heterozygous condition, particularly in the occupational context wherein the exposure to chemical and physical agents may worsen the disorder

Biochem Pharmacol, 2009

3 Results 3.1 Effect of glycitin on PTZ induced seizure The seizure induced by a subthreshold dose of PTZ resulted in the prototyped movements such as myoclonic jerks and generalized tonic-clonic seizures, in all groups