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Copper is an essential trace metal and a required cofactor for enzymes central to skin biology, including lysyl oxidase (which cross-links collagen and elastin) and superoxide dismutase (an antioxidant enzyme)

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(2009) demonstrated that retroviral overexpression of Olig2 in transplanted F3 human NPCs enhanced oligodendrocyte replacement accompanied by a significant increase in white matter sparing, decreased lesion size, increased myelin thickness and improved locomotor recovery compared to non-transduced F3 NPCs