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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

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While B12 alone may not cure structural causes, it significantly accelerates nerve repair and supports vascular healthoften reducing episode frequency and severity when combined with structural care