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The resulting increase in Treg abundance dampens metaflammation and reduces circulating and islet levels of TNF-, IL-1, and IFN-, which in turn alleviates -cell ER stress and protects against cytokine-induced apoptosis ( Proteobacteria

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Tofacitinib also significantly inhibits IL-22-induced CXCL1 and CXCL5 expression in human colonic tissues, suggesting that targeting the IL-22/CXC chemokine axis through JAK/STAT inhibition may be a viable therapeutic strategy