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Yakugaku Zasshi 2011, 131 (5), 739744

Gomez D, Swisher SG , Heymach J

It promotes new blood-vessel growth, which is not something to switch on blindly, given how many cancers depend on it

Additionally, increased levels of heparinase following grafting may lead to a decrease in heparan sulfate at the dermo-epidermal junction (DEJ), which can enhance factors involved in melanocyte activity and pigmentation 7